| Win | 16-5 (1) | Patricio Freire  | Decision (Unanimous) |  | UFC 314: Volkanovski vs Lopes | Apr 12, 2025 | 3 | 5:00 | Miami, Florida, United States  |
| Loss | 15-5 (1) | Brian Ortega | Submission (Arm-Triangle Choke) |  | UFC Fight Night: Moreno vs Royval 2 | Feb 24, 2024 | 3 | 0:58 | Mexico City, Mexico  |
| Loss | 15-4 (1) | Alexander Volkanovski  | TKO (Punches) |  | UFC 290: Volkanovski vs Rodriguez | Jul 08, 2023 | 3 | 4:19 | Las Vegas, Nevada, United States |
| Win | 15-3 (1) | Josh Emmett | Submission (Triangle Choke) |  | UFC 284: Makhachev vs Volkanovski | Feb 11, 2023 | 2 | 4:49 | Perth, Western Australia  |
| Win | 14-3 (1) | Brian Ortega | TKO (Shoulder Injury) |  | UFC Fight Night: Ortega vs Rodriguez | Jul 16, 2022 | 1 | 4:11 | Long Island, New York, United States |
| Loss | 13-3 (1) | Max Holloway | Decision (Unanimous) |  | UFC Fight Night: Holloway vs Rodriguez | Nov 13, 2021 | 5 | 5:00 | Las Vegas, Nevada, United States |
| Cancelled Bout | | Zabit Magomedsharipov  | - | | UFC Fight Night 176: Magomedsharipov vs Rodriguez | Aug 29, 2020 | - | - | Las Vegas, Nevada, United States |
| Win | 13-2 (1) | Jeremy Stephens | Decision (Unanimous) |  | UFC on ESPN2: Weidman vs Reyes | Oct 18, 2019 | 3 | 5:00 | Boston, Massachusetts, United States |
| NC | 12-2 (1) | Jeremy Stephens | No Contest (Accidental Eye Poke) |  | UFC on ESPN+ 17: Rodriguez vs Stephens | Sep 21, 2019 | 1 | 0:15 | Mexico City, Mexico |
| Win | 12-2 | Chan Sung Jung  | KO (Elbow) |  | UFC Fight Night 139: Korean Zombie vs Rodriguez | Nov 10, 2018 | 5 | 4:59 | Denver, Colorado, United States |
| Loss | 11-2 | Frankie Edgar | TKO (Doctor Stoppage) |  | UFC 211: Miocic vs Dos Santos 2 | May 13, 2017 | 2 | 5:00 | Dallas, Texas, United States |
| Win | 11-1 | B.J. Penn | TKO (front kick and punches) |  | UFC Fight Night 103: Rodriguez vs Penn | Jan 15, 2017 | 2 | 0:24 | Phoenix, Arizona, United States |
| Win | 10-1 | Alex Caceres | Decision (split) |  | UFC Fight Night 92: Caceres vs Rodriguez | Aug 06, 2016 | 5 | 5:00 | Salt Lake City, Utah, United States |
| Win | 9-1 | Andre Fili | KO (flying head kick) |  | UFC 197 | Apr 23, 2016 | 2 | 2:15 | Nevada, United States |
| Win | 8-1 | Dan Hooker  | Decision (Unanimous) |  | UFC 192 | Oct 03, 2015 | 3 | 5:00 | Texas, United States |
| Win | 7-1 | Charles Rosa | Decision (split) |  | UFC 188 | Jun 13, 2015 | 3 | 5:00 | Mexico City, Mexico |
| Win | 6-1 | Leonardo Morales | Decision (Unanimous) |  | UFC 180 | Nov 15, 2014 | 3 | 5:00 | Mexico City, Mexico |
| Win | 5-1 | Angelo Duarte | Submission (armbar) | | NP - High Altitude Face Off 6 | Apr 04, 2014 | 1 | 2:12 | Colorado, United States |
| Win | 4-1 | Édgar Juárez | KO (flying knee) | | Mexican Fighter Promotions 14 | Feb 16, 2013 | 1 | 0:13 | Chihuahua, Mexico |
| Loss | 3-1 | Luis Roberto Herrera | KO (punches) | | Mexican Fighter Promotions 13 | Dec 20, 2012 | 1 | 1:21 | Chihuahua, Mexico |
| Win | 3-0 | Carlos Ricardo | Submission (triangle choke) | | The Supreme Cage 1 | Mar 10, 2012 | 3 | 0:50 | Monterrey, Mexico |
| Win | 2-0 | Edgar Balderrama | Submission (Rear-Naked Choke) | | FMP 9 - Jueves DIC 22 | Dec 22, 2011 | 1 | 2:13 | Mexico |
| Win | 1-0 | Jonatan Guzmán | Decision (Unanimous) | | Mexican Fighter Promotions 8 | Oct 10, 2011 | 3 | 3:00 | Mexico City, Mexico |
