| Planned | | Dustin Poirier  | - | | UFC 318: Holloway vs Poirier 3 | Jul 19, 2025 | - | - | New Orleans, Louisiana, United States |
| Loss | 26-8 | Ilia Topuria  | KO (Punch) |  | UFC 308: Topuria vs Holloway | Oct 26, 2024 | 3 | 1:34 | Abu Dhabi, Dubai, United Arab Emirates  |
| Win | 26-7 | Justin Gaethje | KO (Punch) |  | UFC 300: Pereira vs Hill | Apr 13, 2024 | 4 | 4:59 | Las Vegas, Nevada, United States |
| Win | 25-7 | Chan Sung Jung  | TKO (Punches) |  | UFC Fight Night: Holloway vs Korean Zombie | Aug 26, 2023 | 3 | 0:23 | Singapore Indoor Stadium, Kallang, Singapore  |
| Win | 24-7 | Arnold Allen  | Decision (Unanimous) |  | UFC Fight Night: Holloway vs Allen | Apr 15, 2023 | 5 | 5:00 | Las Vegas, Nevada, United States |
| Loss | 23-7 | Alexander Volkanovski  | Decision (Unanimous) |  | UFC 276: Adesanya vs Cannonier | Jul 02, 2022 | 5 | 5:00 | Las Vegas, Nevada, United States |
| Win | 23-6 | Yair Rodriguez  | Decision (Unanimous) |  | UFC Fight Night: Holloway vs Rodriguez | Nov 13, 2021 | 5 | 5:00 | Las Vegas, Nevada, United States |
| Win | 22-6 | Calvin Kattar | Decision (Unanimous) |  | UFC Fight Night 184: Holloway vs Kattar | Jan 16, 2021 | 5 | 5:00 | Las Vegas, Nevada, United States |
| Loss | 21-6 | Alexander Volkanovski | Decision (Split) |  | UFC 251: Usman vs. Masvidal | Jul 11, 2020 | 3 | 5:00 | Abu Dhabi, Dubai, United Arab Emirates |
| Loss | 21-5 | Alexander Volkanovski | Decision (Unanimous) |  | UFC 245: Usman vs Covington | Dec 14, 2019 | 5 | 5:00 | Las Vegas, Nevada, United States |
| Win | 21-4 | Frankie Edgar | Decision (Unanimous) |  | UFC 240: Holloway vs Edgar | Jul 27, 2019 | 5 | 5:00 | Edmonton, Alberta, Canada |
| Loss | 20-4 | Dustin Poirier | Decision (Unanimous) |  | UFC 236: Holloway vs Poirier 2 | Apr 13, 2019 | 5 | 5:00 | Atlanta, Georgia, United States |
| Win | 20-3 | Brian Ortega | TKO (Doctor Stoppage) |  | UFC 231: Holloway vs Ortega | Dec 08, 2018 | 4 | 5:00 | Toronto, Ontario, Canada |
| Win | 19-3 | Jose Aldo  | TKO (Punches) |  | UFC 218: Holloway vs. Aldo 2 | Dec 02, 2017 | 3 | 4:51 | Detroit, Michigan, United States |
| Win | 18-3 | Jose Aldo | TKO (Punches) |  | UFC 212: Aldo vs Holloway | Jun 03, 2017 | 3 | 4:13 | Rio de Janeiro, Brazil |
| Win | 17-3 | Anthony Pettis | TKO (Kick to the Body and Punches) |  | UFC 206: Holloway vs Pettis | Dec 10, 2016 | 3 | 4:50 | Toronto, Ontario, Canada |
| Win | 16-3 | Ricardo Lamas | Decision (unanimous) |  | UFC 199: Rockhold vs Bisping 2 | Jun 04, 2016 | 3 | 5:00 | Inglewood, California, United States |
| Win | 15-3 | Jeremy Stephens | Decision (unanimous) | | UFC 194: Aldo vs McGregor | Dec 12, 2015 | 3 | 5:00 | Las Vegas, United States |
| Win | 14-3 | Charles Oliveira | TKO (Injury) | | UFC Fight Night: Holloway vs Oliveira | Aug 23, 2015 | 1 | 1:39 | Saskatoon, Canada |
| Win | 13-3 | Cub Swanson | Submission (guillotine choke) |  | UFC on Fox: Machida vs. Rockhold | Apr 18, 2015 | 3 | 3:58 | Newark, New Jersey, United States |
| Win | 12-3 | Cole Miller | Decision (unanimous) | | UFC Fight Night: Henderson vs. Thatch | Feb 14, 2015 | 3 | 5:00 | Colorado, United States |
| Win | 11-3 | Akira Corassani | KO (punches) | | UFC Fight Night: Nelson vs. Story | Oct 04, 2014 | 1 | 3:11 | Stockholm, Sweden |
| Win | 10-3 | Clay Collard | TKO (punches) | | UFC Fight Night: Henderson vs. dos Anjos | Aug 23, 2014 | 3 | 3:47 | Oklahoma, United States |
| Win | 9-3 | Andre Fili | Submission (guillotine choke) | | UFC 172 | Apr 26, 2014 | 3 | 3:39 | Maryland, United States |
| Win | 8-3 | Will Chope | TKO (spinning back kick and punches) | | UFC Fight Night: Saffiedine vs. Lim | Jan 04, 2014 | 2 | 2:27 | Marina Bay, Singapore |
| Loss | 7-3 | Conor McGregor  | Decision (unanimous) | | UFC Fight Night: Shogun vs. Sonnen | Aug 17, 2013 | 3 | 5:00 | Boston, United States |
| Loss | 7-2 | Dennis Bermudez | Decision (split) |  | UFC 160 | May 25, 2013 | 3 | 5:00 | Nevada, United States |
| Win | 7-1 | Leonard Garcia | Decision (split) | | UFC 155 | Dec 29, 2012 | 3 | 5:00 | Nevada, United States |
| Win | 6-1 | Justin Lawrence | TKO (punches) | | UFC 150 | Aug 11, 2012 | 2 | 4:49 | Colorado, United States |
| Win | 5-1 | Pat Schilling | Decision (unanimous) | | The Ultimate Fighter: Live Finale | Jun 01, 2012 | 3 | 5:00 | Nevada, United States |
| Loss | 4-1 | Dustin Poirier | Submission (mounted triangle armbar) | | UFC 143 | Feb 04, 2012 | 1 | 3:23 | Las Vegas, Nevada, United States |
| Win | 4-0 | Eddie Rincon | Decision (unanimous) | | UIC 4 - War on the Valley Isle | Jul 01, 2011 | 3 | 5:00 | Hawaii, United States |
| Win | 3-0 | Harris Sarmiento | Decision (split) | | X-1 - Champions 3 | Mar 12, 2011 | 5 | 5:00 | Hawaii, United States |
| Win | 2-0 | Bryson Kamaka | KO (punches) | | X-1 - Island Pride | Nov 06, 2010 | 1 | 3:09 | Hawaii, United States |
| Win | 1-0 | Duke Saragosa | Decision (unanimous) | | X-1 - Heroes | Sep 11, 2010 | 3 | 5:00 | Hawaii, United States |
