| Loss | 24-10-1 (1) | Junior dos Santos  | Decision (Unanimous) |  | Gamebred Bareknuckle MMA: Dos Santos vs. Werdum | Sep 08, 2023 | 3 | 5:00 | Jacksonville, Florida  |
| NC | 24-9-1 (1) | Renan Ferreira | No Contest (Overturned) |  | PFL 2021 #3 | May 06, 2021 | 1 | 2:32 | Atlantic City, New Jersey, United States |
| Win | 24-9-1 | Alexander Gustafsson  | Submission (Armbar) |  | UFC Fight Night: Whittaker vs Till | Jul 25, 2020 | 1 | 2:30 | Abu Dhabi, United Arab Emirates  |
| Loss | 23-9-1 | Alexey Oleinik  | Decision (Split) |  | UFC 249: Ferguson vs Gaethje | May 09, 2020 | 3 | 5:00 | Jacksonville, Florida, United States |
| Loss | 23-8-1 | Alexander Volkov | KO (Punches) |  | UFC Fight Night 127 | Mar 17, 2018 | 4 | 1:38 | London, England, United Kingdom |
| Win | 23-7-1 | Marcin Tybura  | Decision (Unanimous) |  | UFC Fight Night 121: Werdum vs Tybura | Nov 19, 2017 | 5 | 5:00 | Sydney, New South Wales, Australia |
| Win | 22-7-1 | Walt Harris | Submission (armbar) |  | UFC 216: Ferguson vs Lee | Oct 07, 2017 | 1 | 1:05 | Las Vegas, Nevada, United States |
| Loss | 21-7-1 | Alistair Overeem  | Decision (Majority) |  | UFC 213: Nunes vs Shevchenko 2 | Jul 08, 2017 | 33 | 5:00 | Las Vegas, Nevada, United States |
| Win | 21-6-1 | Travis Browne | Decision (unanimous) |  | UFC 203: Miocic vs Overeem | Sep 10, 2016 | 3 | 5:00 | Cleveland, Ohio, United States |
| Loss | 20-6-1 | Stipe Miocic | KO (punch) |  | UFC 198: Werdum vs Miocic | May 14, 2016 | 1 | 2:47 | Curitiba, Paraná, Brazil |
| Win | 20-5-1 | Cain Velasquez | Submission (guillotine Choke) |  | UFC 188: Velasquez vs Werdum | Jun 13, 2015 | 3 | 2:13 | Mexico City, Mexico |
| Win | 19-5-1 | Mark Hunt  | TKO (flying knee and punches) |  | UFC 180: Hunt vs Werdum | Nov 15, 2014 | 2 | 2:27 | Mexico City, Mexico  |
| Win | 18-5-1 | Travis Browne | Decision (unanimous) |  | UFC on Fox 11: Werdum vs Browne | Apr 19, 2014 | 5 | 5:00 | Orlando, United States |
| Win | 17-5-1 | Antonio Rodrigo Nogueira | Verbal Submission (armbar) |  | UFC on FUEL TV 10: Nogueira vs Werdum | Jun 08, 2013 | 2 | 2:41 | Ceara, Brazil |
| Win | 16-5-1 | Mike Russow | TKO (punches) | | UFC 147: Belfort vs Silva 2 | Jun 23, 2012 | 1 | 2:28 | Belo Horizonte, Brazil |
| Win | 15-5-1 | Roy Nelson | Decision |  | UFC 143 | Feb 04, 2012 | 3 | 5:00 | Las Vegas, United States |
| Loss | 14-5-1 | Alistair Overeem | Decision (unanimous) |  | Strikeforce: Heavyweight Grand Prix | Jun 18, 2011 | 3 | 5:00 | Dallas, United States |
| Win | 14-4-1 | Fedor Emelianenko | Submission |  | Strikeforce: Fedor vs. Werdum | Jun 26, 2010 | 1 | 1:09 | San Jose, United States |
| Win | 13-4-1 | Antonio Silva | Decision (unanimous) |  | Strikeforce: Fedor vs. Rogers | Nov 07, 2009 | 3 | 5:00 | Hoffman Estates, United States |
| Win | 12-4-1 | Mike Kyle | Submission (guillotine choke) | | Strikeforce: Carano vs Cyborg | Aug 15, 2009 | 1 | 1:24 | San Jose, United States |
| Loss | 11-4-1 | Junior dos Santos | KO (punches) | | UFC 90 | Oct 25, 2008 | 1 | 1:20 | Rosemont, United States |
| Win | 11-3-1 | Brandon Vera | TKO (punches) |  | UFC 85: Bedlam | Jun 07, 2008 | 1 | 4:40 | London, England |
| Win | 10-3-1 | Gabriel Gonzaga | TKO (punches) | | UFC 80 | Jan 19, 2008 | 2 | 4:34 | Newcastle upon Tyne, England |
| Loss | 9-3-1 | Andrey Arlovski  | Decision (unanimous) | | UFC 70 | Apr 21, 2007 | 3 | 5:00 | Manchester, England  |
| Win | 9-2-1 | Alexander Emelianenko | Submission (arm-triangle choke) | | 2H2H: Pride & Honor | Nov 12, 2006 | 1 | 3:24 | Rotterdam, Netherlands |
| Loss | 8-2-1 | Antonio Rodrigo Nogueira | Decision (unanimous) |  | Pride Critical Countdown Absolute | Jul 01, 2006 | 3 | 5:00 | Saitama, Saitama, Japan |
| Win | 8-1-1 | Alistair Overeem | Submission (kimura) | | Pride Total Elimination Absolute | May 05, 2006 | 2 | 3:43 | Osaka, Osaka, Japan  |
| Win | 7-1-1 | John-Olav Einemo | Decision (unanimous) | | Pride 31 | Feb 26, 2006 | 3 | 5:00 | Saitama, Saitama, Japan |
| Loss | 6-1-1 | Sergei Kharitonov | Decision (split) | | Pride 30 | Oct 23, 2005 | 3 | 5:00 | Saitama, Saitama, Japan |
| Win | 6-0-1 | Roman Zentsov | Submission (triangle armbar) |  | Pride Final Conflict 2005 | Aug 28, 2005 | 1 | 6:01 | Saitama, Saitama, Japan |
| Win | 5-0-1 | Tom Erikson | Submission (rear-naked choke) | | Pride 29 | Feb 20, 2005 | 1 | 5:29 | Saitama, Saitama, Japan |
| Win | 4-0-1 | Ebenezer Fontes Braga | KO (punch) | | Jungle Fight 2 | May 15, 2004 | 2 | 1:28 | Manaus, Brazil |
| Win | 3-0-1 | Gabriel Gonzaga | TKO (punches) | | Jungle Fight 1 | Sep 13, 2003 | 3 | 2:11 | Manaus, Brazil |
| Win | 2-0-1 | Kristof Midoux | Submission (triangle armbar) | | WAFF 2: World Absolute Fight 2 | Mar 22, 2003 | 1 | 4:11 | Marrakech, Morocco |
| Draw | 1-0-1 | James Zikic  | Draw | | MB 8 - Millennium Brawl 8 | Sep 22, 2002 | 3 | 5:00 | High Wykombe, England  |
| Win | 1-0 | Tengiz Tedoradze  | Submission (triangle choke) | | Millennium Brawl 7 | Jun 16, 2002 | 1 | 0:00 | High Wycombe, England |
