| Loss | 30-10 (1) | Max Holloway  | Decision (Unanimous) |  | UFC 318: Holloway vs Poirier 3 | Jul 19, 2025 | 5 | 5:00 | New Orleans, Louisiana, United States |
| Loss | 30-9 (1) | Islam Makhachev  | Submission (Brabo Choke) |  | UFC 302: Makhachev vs Poirier | Jun 01, 2024 | 5 | 2:42 | Newark, New Jersey, United States |
| Win | 30-8 (1) | Benoit Saint-Denis  | KO (Punches) |  | UFC 299: O'Malley vs Vera 2 | Mar 09, 2024 | 2 | 2:32 | Miami, Florida, United States |
| Loss | 29-8 (1) | Justin Gaethje | KO (Head Kick) |  | UFC 291: Poirier vs Gaethje 2 | Jul 29, 2023 | 2 | 1:00 | Salt Lake City, Utah, United States |
| Win | 29-7 (1) | Michael Chandler | Submission (Rear-Naked Choke) |  | UFC 281: Adesanya vs Pereira | Nov 12, 2022 | 3 | 2:00 | New York City, New York, United States |
| Loss | 28-7 (1) | Charles Oliveira  | Submission (Rear-Naked Choke) |  | UFC 269: Oliveira vs Poirier | Dec 11, 2021 | 3 | 1:02 | Las Vegas, Nevada, United States |
| Win | 28-6 (1) | Conor McGregor  | TKO (Doctor Stoppage) |  | UFC 264: Poirier vs McGregor 3 | Jul 10, 2021 | 1 | 5:00 | Las Vegas, Nevada, United States |
| Win | 27-6 (1) | Conor McGregor | KO (Punches) |  | UFC 257: McGregor vs Poirier 2 | Jan 23, 2021 | 2 | 2:32 | Abu Dhabi, Dubai, United Arab Emirates  |
| Win | 26-6 (1) | Dan Hooker  | Decision (Unanimous) |  | UFC Fight Night 174: Poirier vs Hooker | Jun 27, 2020 | 5 | 5:00 | Las Vegas, Nevada, United States |
| Loss | 25-6 (1) | Khabib Nurmagomedov | Submission (Rear-Naked Choke) |  | UFC 242: Khabib vs Poirier | Sep 07, 2019 | 3 | 2:06 | Abu Dhabi, Dubai, United Arab Emirates |
| Win | 25-5 (1) | Max Holloway | Decision (Unanimous) |  | UFC 236: Holloway vs Poirier 2 | Apr 13, 2019 | 5 | 5:00 | Atlanta, Georgia, United States |
| Win | 24-5 (1) | Eddie Alvarez | TKO (Punches) |  | UFC on FOX 30: Alvarez vs Poirier 2 | Jul 28, 2018 | 2 | 4:05 | Calgary, Alberta, Canada |
| Win | 23-5 (1) | Justin Gaethje | TKO (punches) |  | UFC on FOX 29: Gaethje vs Poirier | Apr 14, 2018 | 4 | 0:33 | Glendale, Arizona, United States |
| Win | 22-5 (1) | Anthony Pettis | Submission (Body Triangle) |  | UFC Fight Night 120: Poirier vs Pettis | Nov 11, 2017 | 3 | 2:08 | Norfolk, Virginia, United States |
| NC | 21-5 (1) | Eddie Alvarez | NC (Accidental Knee to Head of Grounded Fighter) |  | UFC 211: Miocic vs Dos Santos 2 | May 13, 2017 | 2 | 4:12 | Dallas, Texas, United States |
| Win | 21-5 | Jim Miller | Decision (majority) |  | UFC 208: Holm vs de Randamie | Feb 11, 2017 | 3 | 5:00 | Brooklyn, New York, United States |
| Loss | 20-5 | Michael Johnson | KO (punches) |  | UFC Fight Night 94: Poirier vs Johnson | Sep 17, 2016 | 1 | 1:35 | Hidalgo, Texas, United States |
| Win | 20-4 | Bobby Green | KO (punches) |  | UFC 199 | Jun 04, 2016 | 1 | 2:52 | California, United States |
| Win | 19-4 | Joseph Duffy | Decision (unanimous) |  | UFC 195 | Jan 02, 2016 | 3 | 5:00 | Las Vegas, Nevada, United States |
| Win | 18-4 | Yancy Medeiros | TKO (body kick and punches) | | UFC Fight Night: Boetsch vs. Henderson | Jun 06, 2015 | 1 | 2:38 | Louisiana, United States |
| Win | 17-4 | Carlos Diego Ferreira | KO (punches) | | UFC Fight Night: Mendes vs. Lamas | Apr 04, 2015 | 1 | 3:45 | Virginia, United States |
| Loss | 16-4 | Conor McGregor | TKO (punches) |  | UFC 178 | Dec 27, 2014 | 1 | 1:46 | Las Vegas, United States |
| Win | 16-3 | Akira Corassani | TKO (Punches) | | The Ultimate Fighter Nations Finale: Bisping vs. Kennedy | Apr 16, 2014 | 2 | 0:42 | Quebec, Canada |
| Win | 15-3 | Diego Brandão | KO (punches) |  | UFC 168 | Dec 28, 2013 | 1 | 4:54 | Las Vegas, Nevada, United States |
| Win | 14-3 | Erik Koch | Decision (unanimous) | | UFC 164 | Aug 31, 2013 | 3 | 5:00 | Wisconsin, United States |
| Loss | 13-3 | Cub Swanson | Decision (unanimous) | | UFC on Fuel TV: Barao vs. McDonald | Feb 16, 2013 | 3 | 5:00 | London, England |
| Win | 13-2 | Jonathan Brookins | Submission (D'Arce choke) | | The Ultimate Fighter: Team Carwin vs. Team Nelson Finale | Dec 15, 2012 | 1 | 4:15 | Las Vegas, Nevada, United States |
| Loss | 12-2 | Chan Sung Jung  | Technical Submission (D'Arce choke) |  | UFC on Fuel TV: Korean Zombie vs. Poirier | May 15, 2012 | 4 | 1:07 | Virginia, United States |
| Win | 12-1 | Max Holloway | Submission (mounted triangle armbar) | | UFC 143 | Feb 04, 2012 | 1 | 3:23 | Las Vegas, Nevada, United States |
| Win | 11-1 | Pablo Garza | Submission (D'Arce choke) | | UFC on Fox: Velasquez vs. dos Santos | Nov 12, 2011 | 2 | 1:32 | California, United States |
| Win | 10-1 | Jason Young | Decision (unanimous) | | UFC 131 | Jun 11, 2011 | 3 | 5:00 | Columbia, Canada |
| Win | 9-1 | Josh Grispi | Decision (unanimous) | | UFC 125 | Jan 01, 2011 | 3 | 5:00 | Las Vegas, Nevada, United States |
| Win | 8-1 | Zach Micklewright | TKO (punches) | | WEC 52 | Nov 11, 2010 | 1 | 0:53 | Las Vegas, Nevada, United States |
| Loss | 7-1 | Danny Castillo | Decision (unanimous) | | WEC 50 | Aug 18, 2010 | 3 | 5:00 | Las Vegas, Nevada, United States |
| Win | 7-0 | Derek Gauthier | KO (punch) | | Ringside MMA | Jun 18, 2010 | 1 | 0:57 | Quebec, Canada |
| Win | 6-0 | Derek Krantz | Submission (armbar) | | USA MMA - Night of Champions 2 | Mar 06, 2010 | 2 | 3:35 | Louisiana, United States |
| Win | 5-0 | Ronny Lis | Technical Submission (armbar) | | USA MMA - Border War 2 | Nov 13, 2009 | 1 | 0:51 | Louisiana, United States |
| Win | 4-0 | Daniel Watts | KO (punches) | | Bang FC | Oct 31, 2009 | 1 | 1:26 | Mississippi, United States |
| Win | 3-0 | Joe Torrez | TKO (punches) | | USA MMA 8 - Natural Disaster 3 | Aug 01, 2009 | 1 | 2:37 | Louisiana, United States |
| Win | 2-0 | Nate Jolly | Submission (armbar) | | Cajun FC | Jun 26, 2009 | 2 | 3:54 | Louisiana, United States |
| Win | 1-0 | Aaron Suarez | KO (punches) | | USA MMA 7 - River City Rampage | May 16, 2009 | 1 | 1:19 | Louisiana, United States |
