| Win | 26-5 | Rafael Fiziev  | Decision (Unanimous) |  | UFC 313: Pereira vs Ankalaev | Mar 08, 2025 | 3 | 5:00 | Las Vegas, Nevada, United States  |
| Loss | 25-5 | Max Holloway | KO (Punch) |  | UFC 300: Pereira vs Hill | Apr 13, 2024 | 4 | 4:59 | Las Vegas, Nevada, United States |
| Win | 25-4 | Dustin Poirier | KO (Head Kick) |  | UFC 291: Poirier vs Gaethje 2 | Jul 29, 2023 | 2 | 1:00 | Salt Lake City, Utah, United States |
| Win | 24-4 | Rafael Fiziev | Decision (Majority) |  | UFC 286: Edwards vs Usman 3 | Mar 18, 2023 | 3 | 5:00 | London, England  |
| Loss | 23-4 | Charles Oliveira  | Submission (rear-naked choke) |  | UFC 274: Oliveira vs Gaethje | May 07, 2022 | 1 | 3:22 | Phoenix, Arizona, United States |
| Win | 23-3 | Michael Chandler | Decision (Unanimous) |  | UFC 268: Usman vs Covington 2 | Nov 06, 2021 | 3 | 5:00 | New York City, New York, United States |
| Loss | 22-3 | Khabib Nurmagomedov  | Technical Submission (Triangle Choke) |  | UFC 254: Khabib vs Gaethje | Oct 24, 2020 | 2 | 1:34 | Abu Dhabi, Dubai, United Arab Emirates  |
| Cancelled Bout | | Khabib Nurmagomedov | - |  | UFC 253: Nurmagomedov vs Gaethje | Sep 19, 2020 | - | - | Las Vegas, Nevada, United States |
| Win | 22-2 | Tony Ferguson | TKO (Punches) |  | UFC 249: Ferguson vs Gaethje | May 09, 2020 | 5 | 3:39 | Jacksonville, Florida, United States |
| Cancelled Bout | | Tony Ferguson | - |  | UFC 249: Ferguson vs Gaethje | Apr 18, 2020 | - | - | Lemoore, California, United States |
| Win | 21-2 | Donald Cerrone | TKO (Punches) |  | UFC on ESPN+ 16: Cowboy vs Gaethje | Sep 14, 2019 | 1 | 4:18 | Vancouver, British Columbia, Canada |
| Win | 20-2 | Edson Barboza | KO (Punch) |  | UFC on ESPN 2 | Mar 30, 2019 | 1 | 2:30 | Philadelphia, Pennsylvania, United States |
| Win | 19-2 | James Vick | KO (Punches) |  | UFC Fight Night 135: Gaethje vs Vick | Aug 25, 2018 | 1 | 1:27 | Lincoln, Nebraska, United States |
| Loss | 18-2 | Dustin Poirier | TKO (punches) |  | UFC on FOX 29: Gaethje vs Poirier | Apr 14, 2018 | 4 | 0:33 | Glendale, Arizona, United States |
| Loss | 18-1 | Eddie Alvarez | KO (Knee) |  | UFC 218 | Dec 02, 2017 | 3 | 3:59 | Detroit, Michigan, United States |
| Win | 18-0 | Michael Johnson | TKO (Punches and Knees) |  | The Ultimate Fighter 25 Finale | Jul 08, 2017 | 2 | 4:48 | Las Vegas, Nevada, United States |
| Win | 17-0 | Luiz Firmino | TKO (doctor stoppage) |  | WSOF 34: Gaethje vs Firmino | Dec 31, 2016 | 3 | 5:00 | New York City, New York, United States |
| Cancelled Bout | | Ozzy Dugulubgov | - |  | WSOF 33 | Oct 07, 2016 | - | - | Kansas City, Missouri, United States |
| Win | 16-0 | Brian Foster | TKO (Leg Kicks) |  | WSOF 29 | Mar 12, 2016 | 1 | 1:43 | Loveland, United States |
| Win | 15-0 | Luis Palomino  | TKO (punches) |  | WSOF 23 | Sep 18, 2015 | 2 | 4:30 | Phoenix, Arizona, United States |
| Win | 14-0 | Luis Palomino | TKO (leg kicks and punches) |  | WSOF 19 | Mar 28, 2015 | 3 | 3:57 | Phoenix, Arizona, United States |
| Win | 13-0 | Melvin Guillard | Decision (split) |  | WSOF 15 | Nov 15, 2014 | 3 | 5:00 | Tampa, Florida, United States |
| Win | 12-0 | Nick Newell | TKO (punch) |  | WSOF 11 | Jul 05, 2014 | 2 | 3:09 | Daytona Beach, Florida, United States |
| Win | 11-0 | Richard Patishnock | TKO (punches and elbows) |  | WSOF 8 | Jan 18, 2014 | 1 | 1:09 | Hollywood, Florida, United States |
| Win | 10-0 | Dan Lauzon | KO (punches) | | WSOF 6 | Oct 28, 2013 | 2 | 1:40 | Coral Gables, Florida, United States |
| Win | 9-0 | Brian Cobb | TKO (leg kicks) | | WSOF 3 | Jun 14, 2013 | 3 | 2:19 | Las Vegas, Nevada, United States |
| Win | 8-0 | Gesias Cavalcante | TKO (doctor stoppage) | | WSOF 2 | Mar 23, 2013 | 1 | 2:27 | Atlantic City, New Jersey, United States |
| Win | 7-0 | Adrian Valdez | TKO (punches) | | RITC - Rage in the Cage 164 | Nov 16, 2012 | 2 | 0:19 | Chandler, Arizona, United States |
| Win | 6-0 | Drew Fickett | KO (punch) | | RITC - Rage in the Cage 163 | Oct 20, 2012 | 1 | 0:12 | Chandler, Arizona, United States |
| Win | 5-0 | Sam Young | Submission (rear-naked choke) | | RITC - Rage in the Cage 162 | Sep 29, 2012 | 2 | 1:58 | Chandler, Arizona, United States |
| Win | 4-0 | Marcus Edwards | Decision (unanimous) | | ROF 43 - Bad Blood | Jun 02, 2012 | 3 | 5:00 | Broomfield, Colorado, United States |
| Win | 3-0 | Donnie Bell | TKO (punches) | | ROF 42 - Who's Next | Dec 17, 2011 | 2 | 2:57 | Broomfield, Colorado, United States |
| Win | 2-0 | Joe Kelso | TKO (punches) | | BTT MMA 2 - Genesis | Oct 01, 2011 | 1 | 4:32 | Pueblo, Colorado, United States |
| Win | 1-0 | Kevin Croom | KO (slam) | | ROF 41 - Bragging Rights | Aug 10, 2011 | 1 | 1:01 | Broomfield, Colorado, United States |
