| Sieg | 21-4 | Joaquin Buckley  | Decision (Unanimous) |  | UFC Fight Night: Usman vs Buckley | Jun 14, 2025 | 5 | 5:00 | Atlanta, Georgia, United States |
| Cancelled Bout | | Jack Della Maddalena  | - | | UFC 312: Du Plessis vs Strickland 2 | Feb 08, 2025 | - | - | Sydney, New South Wales, Australia |
| Niederlage | 20-4 | Khamzat Chimaev  | Decision (Majority) |  | UFC 294: Makhachev vs Volkanovski 2 | Oct 21, 2023 | 3 | 5:00 | Abu Dhabi, United Arab Emirates  |
| Niederlage | 20-3 | Leon Edwards  | Decision (Unanimous) |  | UFC 286: Edwards vs Usman 3 | Mar 18, 2023 | 5 | 5:00 | London, England  |
| Niederlage | 20-2 | Leon Edwards | KO (head kick) |  | UFC 278: Usman vs Edwards 2 | Aug 20, 2022 | 4 | 4:04 | Salt Lake City, Utah, United States |
| Sieg | 20-1 | Colby Covington | Decision (Unanimous) |  | UFC 268: Usman vs Covington 2 | Nov 06, 2021 | 5 | 5:00 | New York City, New York, United States |
| Sieg | 19-1 | Jorge Masvidal | KO (Punch) |  | UFC 261: Usman vs Masvidal 2 | Apr 24, 2021 | 2 | 1:02 | Las Vegas, Nevada, United States |
| Sieg | 18-1 | Gilbert Burns  | TKO (Punches) |  | UFC 258: Usman vs Burns | Feb 13, 2021 | 3 | 0:34 | Las Vegas, Nevada, United States |
| Cancelled Bout | | Gilbert Burns | - | | UFC 256 | Dec 12, 2020 | - | - | Las Vegas, Nevada, United States |
| Sieg | 17-1 | Jorge Masvidal | Decision (Unanimous) |  | UFC 251: Usman vs. Masvidal | Jul 11, 2020 | 5 | 5:00 | Abu Dhabi, Dubai, United Arab Emirates |
| Sieg | 16-1 | Colby Covington | TKO (Punches) |  | UFC 245: Usman vs Covington | Dec 14, 2019 | 5 | 4:10 | Las Vegas, Nevada, United States |
| Sieg | 15-1 | Tyron Woodley | Decision (Unanimous) |  | UFC 235 | Mar 02, 2019 | 5 | 5:00 | Las Vegas, Nevada, United States |
| Sieg | 14-1 | Rafael dos Anjos | Decision (Unanimous) |  | The Ultimate Fighter 28 Finale | Nov 30, 2018 | 5 | 5:00 | Las Vegas, Nevada, United States |
| Sieg | 13-1 | Demian Maia | Decision (Unanimous) |  | UFC Fight Night 129: Usman vs Maia | May 19, 2018 | 5 | 5:00 | Santiago, Chile  |
| Sieg | 12-1 | Emil Weber Meek  | Decision (Unanimous) |  | UFC Fight Night 124: Stephens vs. Choi | Jan 14, 2018 | 3 | 5:00 | St. Louis, Missouri, United States |
| Sieg | 11-1 | Sérgio Moraes | KO (punches) |  | UFC Fight Night 116: Rockhold vs Branch | Sep 16, 2017 | 1 | 2:48 | Pittsburgh, Pennsylvania, United States |
| Sieg | 10-1 | Sean Strickland | Decision (unanimous) |  | UFC 210: Cormier vs Johnson 2 | Apr 08, 2017 | 3 | 5:00 | Buffalo, New York, United States |
| Sieg | 9-1 | Warlley Alves | Decision (unanimous) |  | UFC Fight Night 100: Bader vs Nogueira 2 | Nov 19, 2016 | 3 | 5:00 | Sao Paulo, Brazil |
| Sieg | 8-1 | Alexander Yakovlev  | Decision (unanimous) |  | UFC on FOX 20: Holm vs Shevchenko | Jul 23, 2016 | 3 | 5:00 | Chicago, United States |
| Sieg | 7-1 | Leon Edwards | Decision (unanimous) |  | UFC on Fox: dos Anjos vs. Cerrone 2 | Dec 19, 2015 | 3 | 5:00 | Florida, United States |
| Sieg | 6-1 | Hayder Hassan | Submission (arm-triangle choke) |  | The Ultimate Fighter: American Top Team vs. Blackzilians Finale | Jul 12, 2015 | 2 | 1:19 | Nevada, United States |
| Sieg | 5-1 | Marcus Hicks | TKO (punches) |  | Legacy FC 33 | Jul 18, 2014 | 2 | 5:00 | Texas, United States |
| Sieg | 4-1 | Lenny Lovoto | TKO (punches) |  | Legacy FC 30 | Apr 04, 2014 | 3 | 1:04 | New Mexico, United Sates |
| Sieg | 3-1 | Steven Rodriguez  | TKO (punches) |  | Legacy FC 27 | Jan 31, 2014 | 1 | 1:31 | Texas, United States |
| Sieg | 2-1 | Rashid Abdullah | TKO (punches) |  | VFC 41 | Dec 14, 2013 | 1 | 3:49 | Nebraska, United States |
| Niederlage | 1-1 | Jose Caceres | Submission (rear-naked choke) |  | CFA 11 | May 24, 2013 | 1 | 3:47 | Florida, United States |
| Sieg | 1-0 | David Glover | TKO (punches) | | RFA 5 | Nov 30, 2012 | 2 | 4:50 | Nebraska, United States |
