| Win | 23-10 | Alan Belcher  | TKO (Punches) |  | GFC 7 - Gamebred Fighting Championship 7 | Mar 02, 2024 | 2 | 4:39 | Orlando, Florida |
| Win | 22-10 | Fabricio Werdum  | Decision (Unanimous) |  | Gamebred Bareknuckle MMA: Dos Santos vs. Werdum | Sep 08, 2023 | 3 | 5:00 | Jacksonville, Florida |
| Loss | 21-10 | Yorgan De Castro  | TKO (Shoulder Injury) |  | Eagle FC 47: Dos Santos vs De Castro | May 20, 2022 | 3 | 0:35 | Miami, Florida, United States |
| Loss | 21-9 | Ciryl Gane  | TKO (Elbow) |  | UFC 256: Figueiredo vs Moreno | Dec 12, 2020 | 2 | 2:34 | Las Vegas, Nevada, United States |
| Loss | 21-8 | Jairzinho Rozenstruik  | TKO (Punches) |  | UFC 252: Miocic vs Cormier 3 | Aug 15, 2020 | 2 | 3:47 | Las Vegas, Nevada, United States |
| Loss | 21-7 | Curtis Blaydes | TKO (Punches) |  | UFC on ESPN+ 24: Blaydes vs Dos Santos | Jan 25, 2020 | 2 | 1:06 | Raleigh, North Carolina, United States |
| Cancelled Bout | | Alexander Volkov  | - |  | UFC on ESPN+ 21: Magomedsharipov vs Kattar | Nov 09, 2019 | - | - | Moscow, Russia |
| Loss | 21-6 | Francis Ngannou | TKO (Punches) |  | UFC on ESPN 3: Dos Santos vs N'Gannou | Jun 29, 2019 | 1 | 1:11 | Minneapolis, Minnesota, United States |
| Win | 21-5 | Derrick Lewis | TKO (Punches) |  | UFC Fight Night: 146 Lewis vs Dos Santos | Mar 09, 2019 | 2 | 1:58 | Wichita, Kansas, United States |
| Win | 20-5 | Tai Tuivasa  | TKO (Punches) |  | UFC Fight Night 142: Dos Santos vs Tuivasa | Dec 01, 2018 | 2 | 2:30 | Adelaide, South Australia |
| Win | 19-5 | Blagoi Ivanov  | Decision (unanimous) |  | UFC Fight Night 133: Dos Santos vs Ivanov | Jul 14, 2018 | 5 | 5:00 | Boise, Idaho, United States |
| Loss | 18-5 | Stipe Miocic | TKO (Punches) |  | UFC 211: Miocic vs Dos Santos 2 | May 13, 2017 | 1 | 2:22 | Dallas, Texas, United States |
| Win | 18-4 | Ben Rothwell | Decision (Unanimous) |  | UFC Fight Night 86: Rothwell vs Dos Santos | Apr 10, 2016 | 5 | 5:00 | Zagreb, Croatia |
| Loss | 17-4 | Alistair Overeem  | TKO (Punches) |  | UFC on FOX: Dos Anjos vs Cerrone 2 | Dec 19, 2015 | 2 | 4:43 | Orlando, United States |
| Win | 17-3 | Stipe Miocic | Decision (unanimous) |  | UFC on Fox: Dos Santos vs Miocic | Dec 13, 2014 | 5 | 5:00 | Phoenix, United States |
| Loss | 16-3 | Cain Velasquez | TKO (slam and punches) |  | UFC 166: Velasquez vs Dos Santos III | Oct 19, 2013 | 5 | 3:09 | Houston, Texas, United States |
| Win | 16-2 | Mark Hunt  | KO (spinning heel kick & punch) |  | UFC 160: Velasquez vs Silva 2 | May 25, 2013 | 3 | 4:18 | Las Vegas, United States |
| Loss | 15-2 | Cain Velasquez | Decision (Unanimous) | | UFC 155: Dos Santos vs Velasquez II | Dec 29, 2012 | 5 | 5:00 | Las Vegas, United States |
| Win | 15-1 | Frank Mir | TKO (punches) |  | UFC 146: Dos Santos vs Mir | May 26, 2012 | 2 | 3:04 | Las Vegas, United States |
| Win | 14-1 | Cain Velasquez | KO (punches) | | UFC: Velasquez vs Dos Santos | Nov 12, 2011 | 1 | 1:04 | Anaheim, United States |
| Win | 13-1 | Shane Carwin | Decision (unanimous) |  | UFC 131 | Jun 11, 2011 | 3 | 5:00 | Vancouver, Canada |
| Win | 12-1 | Roy Nelson | Decision (unanimous) |  | UFC 117 | Aug 07, 2010 | 3 | 5:00 | Oakland, United States |
| Win | 11-1 | Gabriel Gonzaga | KO (punches) |  | UFC Live: Vera vs. Jones | Mar 21, 2010 | 1 | 3:53 | Broomfield, United States |
| Win | 10-1 | Gilbert Yvel | TKO (strikes) |  | UFC 108 | Jan 02, 2010 | 1 | 2:07 | Las Vegas, United States |
| Win | 9-1 | Mirko Filipović  | Submission (eye injury) |  | UFC 103 | Sep 19, 2009 | 3 | 2:00 | Dallas, United States |
| Win | 8-1 | Stefan Struve | TKO (punches) |  | UFC 95: Sanchez vs. Stevenson | Feb 21, 2009 | 1 | 0:54 | London, England  |
| Win | 7-1 | Fabricio Werdum | KO (punches) | | UFC 90 | Oct 25, 2008 | 1 | 1:20 | Rosemont, United States |
| Win | 6-1 | Geronimo dos Santos | TKO (cut) | | Demo Fight 3 | May 24, 2008 | 1 | 0:44 | Salvador, Bahia, Brazil |
| Loss | 5-1 | Joaquim Ferreira | Submission (armbar) | | MTL: Final | Nov 10, 2007 | 1 | 1:13 | São Paulo, Brazil |
| Win | 5-0 | Jair Goncalves | KO (soccer kick) | | Mo Team League 2 | Sep 29, 2007 | 1 | 2:52 | São Paulo, Brazil |
| Win | 4-0 | Edson Silva | TKO (doctor stoppage) | | XFC: Brazil | Apr 29, 2007 | 1 | 8:45 | Rio de Janeiro, Brazil |
| Win | 3-0 | Joaquim Ferreira | Submission (exhaustion) | | XFC: Brazil | Apr 29, 2007 | 1 | 5:00 | Rio de Janeiro, Brazil |
| Win | 2-0 | Eduardo Maiorino | Submission | | Minotauro Fights 5 | Dec 09, 2006 | 1 | 0:50 | São Bernardo do Campo |
| Win | 1-0 | Jailson Silva Santos | TKO (punches) | | Demo Fight 1 | Jul 16, 2006 | 1 | 2:58 | Salvador, Bahia, Brazil |
