| Planned | | Tallison Teixeira  | - |  | UFC Fight Night: Lewis vs Teixeira | Jul 12, 2025 | - | - | Nashville, Tennessee, United States  |
| Cancelled Bout | | Jhonata Diniz | - |  | UFC Fight Night: Moreno vs Albazi | Nov 02, 2024 | - | - | Edmonton, Alberta, Canada  |
| Win | 28-12 (1) | Rodrigo Nascimento | TKO (Punches) |  | UFC Fight Night: Lewis vs Nascimento | May 11, 2024 | 3 | 0:49 | St. Louis, Missouri, United States |
| Loss | 27-12 (1) | Jailton Almeida | Decision (Unanimous) |  | UFC Fight Night: Almeida vs Lewis | Nov 04, 2023 | 5 | 5:00 | Sao Paulo, Brazil |
| Win | 27-11 (1) | Marcos Rogerio de Lima | TKO (Punches) |  | UFC 291: Poirier vs Gaethje 2 | Jul 29, 2023 | 1 | 0:33 | Salt Lake City, Utah, United States |
| Loss | 26-11 (1) | Sergey Spivak  | Submission (Arm-Triangle Choke) |  | UFC Fight Night: Lewis vs Spivak | Feb 04, 2023 | 1 | 3:05 | Las Vegas, Nevada, United States |
| Cancelled Bout | | Sergey Spivak | - |  | UFC Fight Night: Lewis vs Spivak | Nov 19, 2022 | - | - | Las Vegas, Nevada, United States |
| Loss | 26-10 (1) | Sergey Pavlovich  | TKO (Punches) |  | UFC 277: Peña vs Nunes 2 | Jul 30, 2022 | 1 | 0:55 | Dallas, Texas, United States |
| Loss | 26-9 (1) | Tai Tuivasa  | KO (Elbows) |  | UFC 271: Adesanya vs Whittaker 2 | Feb 12, 2022 | 2 | 1:40 | Houston, Texas, United States |
| Win | 26-8 (1) | Chris Daukaus | TKO (Punches) |  | UFC Fight Night: Lewis vs Daukaus | Dec 18, 2021 | 1 | 3:36 | Las Vegas, Nevada, United States |
| Loss | 25-8 (1) | Ciryl Gane  | TKO (Punches) |  | UFC 265: Lewis vs Gane | Aug 07, 2021 | 3 | 4:11 | Houston, Texas, United States |
| Win | 25-7 (1) | Curtis Blaydes | KO (Punch) |  | UFC Fight Night 185: Blaydes vs Lewis | Feb 20, 2021 | 2 | 1:26 | Las Vegas, Nevada, United States |
| Cancelled Bout | | Curtis Blaydes | - |  | UFC Fight Night 184: Blaydes vs Lewis | Nov 28, 2020 | - | - | Las Vegas, Nevada, United States |
| Win | 24-7 (1) | Alexey Oleinik | TKO (Punches) |  | UFC Fight Night: Lewis vs Oleinik | Aug 08, 2020 | 3 | 0:21 | Las Vegas, Nevada, United States |
| Win | 23-7 (1) | Ilir Latifi  | Decision (Unanimous) |  | UFC 247: Jones vs Reyes | Feb 08, 2020 | 3 | 5:00 | Houston, Texas, United States |
| Win | 22-7 (1) | Blagoi Ivanov  | Decision (Split) |  | UFC 244: Masvidal vs Diaz | Nov 02, 2019 | 3 | 5:00 | New York City, New York, United States |
| Loss | 21-7 (1) | Junior dos Santos | TKO (Punches) |  | UFC Fight Night: 146 Lewis vs Dos Santos | Mar 09, 2019 | 2 | 1:58 | Wichita, Kansas, United States |
| Loss | 21-6 (1) | Daniel Cormier | Submission (Rear-Naked Choke) |  | UFC 230: Cormier vs Lewis | Nov 03, 2018 | 2 | 2:14 | New York City, New York, United States |
| Win | 21-5 (1) | Alexander Volkov | KO (Punches) |  | UFC 229: Khabib vs McGregor | Oct 06, 2018 | 3 | 4:49 | Las Vegas, Nevada, United States |
| Win | 20-5 (1) | Francis Ngannou | Decision (Unanimous) |  | UFC 226: Miocic vs Cormier | Jul 07, 2018 | 3 | 5:00 | Last Vegas, Nevada, United States |
| Win | 19-5 (1) | Marcin Tybura  | KO (Punches) |  | UFC Fight Night 126: Cowboy vs Medeiros | Feb 18, 2018 | 3 | 2:48 | Austin, Texas, United States |
| Loss | 18-5 (1) | Mark Hunt  | TKO (Punches) |  | UFC Fight Night 110: Lewis vs Hunt | Jun 10, 2017 | 4 | 3:51 | Auckland, New Zealand |
| Win | 18-4 (1) | Travis Browne | KO (punches) |  | UFC Fight Night 105: Lewis vs Browne | Feb 19, 2017 | 2 | 3:12 | Halifax, Nova Scotia, Canada |
| Win | 17-4 (1) | Shamil Abdurahimov | TKO (Punches) |  | UFC Fight Night 102: Lewis vs Abdurakhimov | Dec 09, 2016 | 4 | 3:42 | Albany, New York, United States |
| Win | 16-4 (1) | Roy Nelson | Decision (split) |  | UFC Fight Night 90: Dos Anjos vs Alvarez | Jul 07, 2016 | 3 | 5:00 | Las Vegas, Nevada, United States |
| Win | 15-4 (1) | Gabriel Gonzaga | KO (Punches) |  | UFC Fight Night 86: Rothwell vs Dos Santos | Apr 10, 2016 | 1 | 4:48 | Zagreb, Croatia |
| Win | 14-4 (1) | Damian Grabowski | TKO (punches) |  | UFC Fight Night 82: Hendricks vs Thompson | Feb 06, 2016 | 1 | 2:17 | Las Vegas, United States |
| Win | 13-4 (1) | Viktor Pesta  | TKO (punches) |  | UFC 192: Cormier vs Gustafsson | Oct 03, 2015 | 3 | 1:15 | Houston, Texas, United States |
| Loss | 12-4 (1) | Shawn Jordan | TKO (hook kick and punches) |  | UFC Fight Night: Boetsch vs Henderson | Jun 06, 2015 | 2 | 0:48 | New Orleans, United States |
| Win | 12-3 (1) | Ruan Potts | TKO (punches) |  | UFC 184 | Feb 28, 2015 | 2 | 3:18 | Los Angeles, California, United States |
| Loss | 11-3 (1) | Matt Mitrione | KO (punches) |  | UFC Fight Night: Mousasi vs Jacare | Sep 05, 2014 | 1 | 0:41 | Ledyard, United States |
| Win | 11-2 (1) | Guto Inocente | KO (punches) |  | The Ultimate Fighter: Team Edgar vs. Team Penn Finale | Jul 06, 2014 | 1 | 3:30 | Las Vegas, Nevada, United States |
| Win | 10-2 (1) | Jack May | TKO (punches) |  | UFC on Fox: Werdum vs. Browne | Apr 19, 2014 | 1 | 4:23 | Orlando, Florida, United States |
| Win | 9-2 (1) | Ricky Shivers | TKO (punches) | | Legacy FC 18 | Mar 01, 2013 | 3 | 4:22 | Houston, Texas, United States |
| Win | 8-2 (1) | Jared Rosholt | KO (punches) | | Legacy FC 13 | Aug 17, 2012 | 2 | 2:41 | Dallas, Texas, United States |
| Win | 7-2 (1) | Justin Frazier | TKO (knee to the body and punches) | | RFA 2 | Mar 30, 2012 | 1 | 2:37 | Kearney, Nebraska, United States |
| NC | 6-2 (1) | Jeremiah Constant | NC (punches to back of head) | | Fight To Win: Paramount Prize Fighting 2012 | Jan 27, 2012 | 1 | 0:48 | Denver, Colorado, United States |
| Win | 6-2 | Rakim Cleveland | TKO (punches) | | Legacy FC 9 | Dec 16, 2011 | 3 | 3:12 | Houston, Texas, United States |
| Win | 5-2 | Jay Peche | TKO (punches) | | Immortal Kombat Fighting | Sep 03, 2011 | 1 | 0:46 | Spring, Texas, United States |
| Loss | 4-2 | Tony Johnson | Decision (Unanimous) | | BFC - Bellator Fighting Championships 46 | Jun 25, 2011 | 3 | 5:00 | Hollywood, United States |
| Win | 4-1 | Taylor Herbert | TKO (punches) | | International Xtreme Fight Association | Feb 26, 2011 | 1 | 2:14 | Houston, Texas, United States |
| Win | 3-1 | Rakim Cleveland | Submission (armbar) | | Worldwide Gladiator | Nov 12, 2010 | 2 | 1:33 | Pasadena, Texas, United States |
| Win | 2-1 | Ryan Martinez | TKO (punches) | | Fight to Win/King of Champions: Worlds Collide | Jul 24, 2010 | 2 | 1:03 | Denver, Colorado, United States |
| Loss | 1-1 | Shawn Jordan | Decision (unanimous) | | Cajun Fighting Championships - Full Force | Jun 25, 2010 | 3 | 5:00 | Louisiana, United States |
| Win | 1-0 | Nick Mitchell | TKO (punches) | | Worldwide Gladiator | Apr 08, 2010 | 2 | 1:33 | Pasadena, Texas, United States |
